Clinical, pathological and genetic characteristics of 17 unrelated children with Alagille Syndrome
Among children diagnosed with ALGS, cholestasis stands as the most common feature. To minimize the risk of misdiagnosis, genetic testing should be performed on children exhibiting cholestasis, followed by the application of the revised diagnostic criteria for ALGS. While pharmacological therapy has shown effectiveness for ALGS patients, liver transplantation may be considered in instances of severe pruritus.
Authors
- Lili Cao (ORCID: https://orcid.org/0000-0002-6878-4599)
- Fuchuan Wang (ORCID: https://orcid.org/0000-0001-8319-8857)
- Jianguo Yan (ORCID: https://orcid.org/0000-0003-4601-4830)
- Min Zhang (ORCID: https://orcid.org/0009-0002-1427-6721)
- Yi Dong (ORCID: https://orcid.org/0000-0002-0212-1477)
- Yinjie Gao (ORCID: https://orcid.org/0000-0001-6034-1999)
- Zhiqiang Xu
- Danni Feng (ORCID: https://orcid.org/0000-0002-5619-505X)
- Yuanzhi Huang
Institutions
- Peking University (CN)
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- BMC Pediatrics
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1186/s12887-024-04973-y
- Citations
- 4
- Primary Topic
- Pediatric Hepatobiliary Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.29