NXPH4 mediated by m5C contributes to the malignant characteristics of colorectal cancer via inhibiting HIF1A degradation
NXPH4, regulated by m<sup>5</sup>C, promotes malignant tumor progression and regulates the HIF pathway. Consequently, targeting NXPH4 through molecular therapies could potentially serve as an efficacious therapeutic strategy for the management of CRC exhibiting elevated NXPH4 expression.
Authors
- Hang Yin (ORCID: https://orcid.org/0000-0002-9042-6990)
- Lei Yang (ORCID: https://orcid.org/0000-0001-6328-6518)
- Jiawen Shi (ORCID: https://orcid.org/0000-0003-1952-9185)
- Haiyan Xu (ORCID: https://orcid.org/0000-0002-8970-4738)
- Kai Miao
- Xiaojing Zhang (ORCID: https://orcid.org/0000-0001-6206-012X)
- Han Wu (ORCID: https://orcid.org/0000-0002-9829-3600)
- Jianfei Huang (ORCID: https://orcid.org/0000-0002-1276-5962)
- Ziheng Wang (ORCID: https://orcid.org/0000-0001-8873-732X)
- Pingping Sun (ORCID: https://orcid.org/0000-0002-8446-5598)
- Lijun Xu
- Mingyang Zhong
- Zhengyi Lian
- Guyin He
Institutions
- Nantong University (CN)
- University of Macau (MO)
- Affiliated Hospital of Nantong University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1186/s11658-024-00630-5
- Citations
- 17
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.97
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Government of Jiangsu Province
- Nantong University