IL-1β mediates Candida tropicalis-induced immunosuppressive function of MDSCs to foster colorectal cancer
C. tropicalis promotes excessive secretion of IL-1β from MDSCs via the NLRP3 inflammasome. IL-1β further enhances the immunosuppressive function of MDSCs to inhibit antitumor immunity, thus promoting the progression of CRC. Therefore, targeting IL-1β secreted by MDSCs may be a potential immunotherapeutic strategy for the treatment of CRC.
Authors
- Aihua Lin (ORCID: https://orcid.org/0009-0006-6644-1441)
- Pengfei Li (ORCID: https://orcid.org/0000-0002-5928-1578)
- Ying Chen (ORCID: https://orcid.org/0000-0001-6693-682X)
- Tingting Wang (ORCID: https://orcid.org/0000-0002-3809-2209)
- Yuxi Chen (ORCID: https://orcid.org/0000-0001-9450-8793)
- Sunan Shen
- Zhengqian Ren
- Xinyi Pan
- Xiuzhu Wang
- Zhiyong Zhang
Institutions
- China Pharmaceutical University (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1186/s12964-024-01771-y
- Citations
- 15
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.51
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities