Synergistic Activation of LEPR and ADRB2 Induced by Leptin Enhances Reactive Oxygen Specie Generation in Triple-Negative Breast Cancer Cells
This study demonstrates that leptin stimulates the growth and metastasis of TNBC through the activation of both LEPR and ADRB2, resulting in increased ROS production. These findings highlight LEPR and ADRB2 as potential biomarkers and therapeutic targets in TNBC.
Authors
- Yan Yan (ORCID: https://orcid.org/0000-0001-5325-6737)
- Jing Yu (ORCID: https://orcid.org/0000-0002-8694-8948)
- Xiaofei Song
- Junfang Qin (ORCID: https://orcid.org/0000-0001-5959-0402)
- Yu Xie (ORCID: https://orcid.org/0000-0001-5518-3973)
- Yongjun Du
- Chang Liu (ORCID: https://orcid.org/0000-0003-0650-1773)
- Yue Wang (ORCID: https://orcid.org/0000-0002-3241-6356)
Institutions
- Nankai University (CN)
- Tianjin Stomatological Hospital (CN)
Publication Details
- Journal
- Cancer Research and Treatment
- Published
- 2024-08-22
- DOI
- https://doi.org/10.4143/crt.2024.368
- Citations
- 4
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 1.54
Funders
- National Natural Science Foundation of China