A population of Insula neurons encodes for social preference only after acute social isolation in mice
The Insula functions as a multisensory relay involved in socio-emotional processing with projections to sensory, cognitive, emotional, and motivational regions. Notably, the interhemispheric projection from the Insula to the contralateral Insula is a robust yet underexplored connection. Using viral-based tracing neuroanatomy, ex vivo and in vivo electrophysiology, in vivo fiber photometry along with targeted circuit manipulation, we elucidated the nature and role of Insula<sup>Ins</sup> communication in social and anxiety processing in mice. In this study, we 1) characterized the anatomical and molecular profile of the Insula<sup>Ins</sup> neurons, 2) demonstrated that stimulation of this neuronal subpopulation induces excitation in the Insula interhemispheric circuit, 3) revealed that Insula<sup>Ins</sup> neurons are essential for social discrimination after 24 h of isolation in male mice. In conclusion, our findings highlight Insula<sup>Ins</sup> neurons as a distinct class of neurons within the insula and offer new insights into the neuronal mechanisms underlying social behavior.
Authors
- Christelle Glangetas (ORCID: https://orcid.org/0000-0001-9544-4277)
- Erwan Bézard (ORCID: https://orcid.org/0000-0002-0410-4638)
- Anne Taupignon (ORCID: https://orcid.org/0000-0002-4662-7971)
- Stéphanie Caillé (ORCID: https://orcid.org/0000-0002-4906-3091)
- L. Bonamy
- François Georges (ORCID: https://orcid.org/0000-0002-2628-2638)
- Adriane Guillaumin (ORCID: https://orcid.org/0000-0002-6488-3207)
- Évelyne Doudnikoff (ORCID: https://orcid.org/0000-0002-3770-8585)
- Marc Landry (ORCID: https://orcid.org/0000-0003-3936-324X)
- Elodie Ladevèze (ORCID: https://orcid.org/0000-0003-2506-6834)
- Manon Gauthier (ORCID: https://orcid.org/0000-0001-9043-3472)
- Jérôme Baufreton (ORCID: https://orcid.org/0000-0002-2623-6375)
- Thibault Dhellemmes (ORCID: https://orcid.org/0009-0004-2325-8386)
- Anaëlle Braine
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Inserm (FR)
- Université de Poitiers (FR)
- Institut des Maladies Neurodégénératives (FR)
- Institut de Neurosciences Cognitives et Intégratives d’Aquitaine (FR)
- Bordeaux Population Health (FR)
- Laboratoire de Neurosciences Expérimentales et Cliniques
Publication Details
- Journal
- Nature Communications
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1038/s41467-024-51389-4
- Citations
- 9
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.25
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Centre National de la Recherche Scientifique
- Université de Bordeaux