Rh(III)-Catalyzed C(sp<sup>3</sup>)–H Thiolation of 8-Methylquinolines Promoted by Benzoic Anhydride
Herein, we developed a ligand-promoted Rh(III)-catalyzed C(sp3)–H thiolation of 8-methylquinolines. The effect of ligands on improving the activity of the catalytic centers has been studied in detail and proven to be significant. Various substituents are well tolerated under this reaction condition to provide potential precursors for organic synthesis. The mechanistic study suggests that the reaction may proceed through a five-membered rhodacycle intermediate via thiolation twice.
Authors
- Cheng‐Kai Yuan
- Wei‐Yin Sun (ORCID: https://orcid.org/0000-0001-8966-9728)
- Yi Lu (ORCID: https://orcid.org/0000-0002-8767-7801)
- Yifei Wu (ORCID: https://orcid.org/0009-0008-4280-8901)
- Zhen Meng (ORCID: https://orcid.org/0000-0003-0379-8583)
- Yan‐Nian Pan
Institutions
- St. Catherine University (US)
- Collaborative Innovation Center of Advanced Microstructures (CN)
- Nanjing University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1021/acs.joc.4c00559
- Citations
- 2
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities