Open-Face Masks in Radiotherapy: Enhancing Therapeutic Strategies for Head and Neck and Brain Cancer Patients—A Comprehensive Scoping Review

<b>Introduction</b>: The main goal of radiotherapy (RT) is to deliver a precise dose to the target while sparing the surrounding normal tissue and minimizing side effects. Appropriate patient immobilization is crucial, especially for head and neck cancer (HNC) and Brain Cancer (BC). Conventional closed-face masks (CFMs), while effective in minimizing head motion, can cause significant discomfort, anxiety, and claustrophobia. Open-face masks (OFMs) have been developed to increase patient comfort while providing precise immobilization. <b>Methods:</b> Following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) extension for scoping reviews and the Arskey and O'Malley framework, an electronic search of EMBASE, PubMed, SCOPUS, and Web of Science was conducted to identify original studies reporting the use and description of OFMs in clinical practice up to April 2024. The inclusion criteria were English-language articles focusing on OFMs for HNC and BC patients undergoing RT. <b>Results:</b> Of 618 titles, 19 articles fulfilled the selection criteria. Most studies were comparative (<i>n</i> = 13) or observational (<i>n</i> = 6). The articles were categorized by treatment site, resulting in three groups: BC (<i>n</i> = 14, 68.4%), HNC (<i>n</i> = 4, 21.4%), and mixed (<i>n</i> = 2, 10.5%), which includes both BC and HNC. Of note, 82.4% (<i>n</i> = 16) of the included studies were published from 2020 onwards, emphasizing the recent adoption of OFM in clinical practice. <b>Conclusions</b>: The reviewed studies show that OFMs, in combination with SGRT, offer significant advantages in terms of patient comfort and positioning accuracy in HNC and BC treatments. Reproducibility in the sub-millimeter and sub-degree range can be achieved, which supports the use of OFMs in clinical practice. Future research should explore innovative combinations of immobilization and monitoring to further improve RT outcomes and ensure precise treatment while increasing patient comfort.