High-Dimensional Single-Cell Mass Cytometry Demonstrates Differential Platelet Functional Phenotypes in Infants With Congenital Heart Disease
We developed a robust mass cytometry approach to identify platelet phenotypic heterogeneity. Infants with CHD had alterations in distinct subpopulations of platelets with overall reduced aggregatory phenotype and secretory dysfunction. These findings suggest that platelets in infants with CHD may be exhausted due to persistent stimulation and may explain both bleeding and thrombotic vascular complications associated with CHD.
Authors
- Sean X. Gu (ORCID: https://orcid.org/0000-0001-5505-3474)
- Brian S. Marcus (ORCID: https://orcid.org/0000-0001-5775-4143)
- Vivian W. Gu
- Adarsh Varghese (ORCID: https://orcid.org/0000-0001-5563-9993)
- E. Vincent S. Faustino (ORCID: https://orcid.org/0000-0001-6155-2691)
- John Hwa (ORCID: https://orcid.org/0000-0001-7366-2628)
Institutions
- Yale University (US)
- Cardiovascular Research Center (BR)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-08-22
- DOI
- https://doi.org/10.1161/atvbaha.124.321131
- Citations
- 10
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.87
Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases