A Complex Interplay of Tumor Microenvironment Could Enhance Cholangiocarcinoma Progression Even After Surgery: A Prospective Study
CCA has a desmoplastic microenvironment with complex immunologic topography and tumor-reactive stroma. The immune landscape of the peripheral blood mononuclear cells (PBMCs) in CCA patients before treatment could reflect the state of systemic immune function and response to treatments. Our results revealed that T-lymphocytes correlated with better prognosis while macrophages and PD-1<sup>+</sup> expression were associated with poor outcomes.
Authors
- Amal Rayan (ORCID: https://orcid.org/0000-0001-5995-9177)
- Asmaa Mohamed Zahran (ORCID: https://orcid.org/0000-0001-8471-6388)
- Aya Mohammed Mahros (ORCID: https://orcid.org/0000-0002-6849-4065)
- Zeinab Albadry M. Zahran
- Doaa A Gamal
- Heba M. Elmasry
- Khaled Saad (ORCID: https://orcid.org/0000-0002-8473-6116)
- Ahmed S. A. Soliman (ORCID: https://orcid.org/0000-0003-4752-3557)
- Mohsen M Fageeh
- Essam-Eldeen M O Mahran
- Khalid Rezk
- Ahmed Khalid Ibrahim
- Mohamed Ahmed Rizk
- Mohamed Ahmed Bashir
Institutions
- Kafrelsheikh University (EG)
- Al-Azhar University (EG)
- South Valley University (EG)
- Assiut University (EG)
Publication Details
- Journal
- Journal of Clinical Medicine Research
- Published
- 2024-08-01
- DOI
- https://doi.org/10.14740/jocmr5201
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Assiut University