Impact of the First Twenty-Four-Hour Area Under the Concentration-Time Curve/Minimum Inhibitory Concentration of Vancomycin on Treatment Outcomes in Patients With Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia
The first 24-h AUC/MIC had no effect on the treatment efficacy and 30-day survival rates. However, the time to clinical and bacteriological improvement was significantly prolonged in the < 300 group, indicating that the first 24-h AUC/MIC does not affect the rate of therapeutic efficacy but may affect the treatment period.
Authors
- Norihiro Moriwaki
- Toshinobu Hayashi (ORCID: https://orcid.org/0000-0001-6183-4939)
- Mitsuhiro Kamada
- Susumu Kaneshige
- Atsushi Togawa (ORCID: https://orcid.org/0000-0001-6419-8480)
- Masanobu Uchiyama (ORCID: https://orcid.org/0000-0001-6385-5944)
- Takafumi Nakano (ORCID: https://orcid.org/0000-0001-5667-1979)
- Koichi Matsuo
- Keisuke Sato
- Tadahiro Ikeuchi
- Yukiomi Eguchi
- Hidetoshi Kamimura
- M. Higashi
Institutions
- Fukuoka University (JP)
- Fukuoka University Hospital (JP)
Publication Details
- Journal
- Journal of Clinical Medicine Research
- Published
- 2024-08-01
- DOI
- https://doi.org/10.14740/jocmr5238
- Citations
- 1
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.39