Pembrolizumab and Cabozantinib in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Long-term Survival Update with a Biomarker Analysis
Pembrolizumab and cabozantinib provided prolonged encouraging long-term disease control and survival with a maintained favorable safety profile. The prognostic significance of higher density of CD8+, CD103+, and CSF1-R+ cells in TIME deserve further evaluation in similar clinical settings.
Authors
- Ashley A. McCook‐Veal (ORCID: https://orcid.org/0000-0001-5368-4977)
- Robbert J.C. Slebos (ORCID: https://orcid.org/0000-0003-3117-9544)
- Dong M. Shin (ORCID: https://orcid.org/0000-0002-8245-4174)
- Christine H. Chung (ORCID: https://orcid.org/0000-0001-5199-4306)
- Mihir R. Patel (ORCID: https://orcid.org/0000-0001-6477-9728)
- Yuan Liu (ORCID: https://orcid.org/0000-0001-8926-3058)
- William A. Stokes (ORCID: https://orcid.org/0000-0002-1616-7046)
- Jennifer H. Gross (ORCID: https://orcid.org/0000-0002-4241-4821)
- Kedar Kirtane (ORCID: https://orcid.org/0000-0003-1302-9577)
- Asari Ekpenyong (ORCID: https://orcid.org/0000-0002-8515-1304)
- Nabil F. Saba (ORCID: https://orcid.org/0000-0003-4972-1477)
- Nicole C. Schmitt (ORCID: https://orcid.org/0000-0002-0571-3531)
- James E. Bates (ORCID: https://orcid.org/0000-0001-7060-7156)
- Jill Remick (ORCID: https://orcid.org/0000-0002-0241-7622)
- Ritu Chaudhary (ORCID: https://orcid.org/0009-0007-9417-0340)
- Maria I. Poole (ORCID: https://orcid.org/0009-0004-8006-8036)
- Soumon Rudra (ORCID: https://orcid.org/0000-0002-1411-4880)
- Angelo Marra (ORCID: https://orcid.org/0009-0004-0004-4027)
- Yong Teng (ORCID: https://orcid.org/0000-0002-1856-7289)
- Conor Steuer (ORCID: https://orcid.org/0000-0001-6528-6319)
- Mark W. McDonald (ORCID: https://orcid.org/0000-0003-3021-9356)
- Xiaofei Song (ORCID: https://orcid.org/0000-0002-6585-7318)
Institutions
- Emory University (US)
- University of Pittsburgh (US)
- Moffitt Cancer Center (US)
- University of Atlanta (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1202
- Citations
- 8
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.64
Funders
- Emory University
- Moffitt Cancer Center
- Exelixis
- Castle Biosciences
- National Institutes of Health
- Winship Cancer Institute
- National Cancer Institute
- National Institute of Dental and Craniofacial Research