Biological activity of Laurus nobilis L. Leaf and Fruit Extract

The leaves and fruits of Laurus nobilis L. are used in pharmaceutical applications with their various activities such as antioxidant, antimicrobial and anti-inflammatory. In current study, it was aimed to investigate antimicrobial, antiquorum sensing, cytotoxicity and antiviral activity of Laurus nobilis L. leaf and fruit extract prepared by %70 ethanol. This study was carried out in the Department of Medical Microbiology, Faculty of Medicine, Karadeniz Technical University, with Laurel leaves and fruits collected from Trabozon province in the Black Sea region. Antimicrobial activity was investigated by the agar well method. Gram negative, Gram positive bacteria and 2 fungi were used. Chromobacterium violaceum ATCC 12472 and Pseudomonas aeruginosa PAO1 strains were used for antiquorum sensing, antibiofilm and anti swarming activities. The cytotoxic effect of ethanol extract prepared from the leaf and fruit of Laurus nobilis L. plant on Vero, A549 and MDA-MB-231 cell lines was investigated by MTT method. The antiviral effect of the extracts on HSV-1 was investigated by MTT method. Antimicrobial and quorum sensing activity was determined to be moderate. It was understood that the leaf and fruit extracts of Laurus nobilis L. used in the study showed antiproliferative and antiviral effects in a dose-dependent manner. Laurel plant needs to be investigated in more detail using different solvents.