Smart Microneedle Arrays Integrating Cell‐Free Therapy and Nanocatalysis to Treat Liver Fibrosis (Adv. Sci. 31/2024)
Smart Microneedle Arrays for Liver Fibrosis Treatment In article number 2309940, Kai Li, Yu Tao, Mingqiang Li, and co‐workers present a versatile microneedle array integrating cell‐free therapy and nanocatalysis for liver fibrosis treatment. These microneedles release core‐shell nanoparticles encapsulating stem cell secretome, which deactivate hepatic stellate cells, rejuvenate hepatocytes, and suppress inflammation. Additionally, the released nanozymes scavenge reactive oxygen species and alleviate hypoxia. This innovative therapeutic strategy demonstrates remarkable efficacy in treating liver fibrosis. [Image: see text]
Authors
- Ling Long (ORCID: https://orcid.org/0000-0002-5901-5288)
- Yinxiong Li (ORCID: https://orcid.org/0000-0002-8802-7720)
- Hao Tian (ORCID: https://orcid.org/0000-0002-9581-0027)
- Yanteng Xu (ORCID: https://orcid.org/0000-0003-0502-3773)
- Yu Tao (ORCID: https://orcid.org/0000-0001-5087-7474)
- Fenfang Li
- Qingguo Zhong (ORCID: https://orcid.org/0009-0005-4572-4410)
- Yeh‐Hsing Lao (ORCID: https://orcid.org/0000-0002-7990-199X)
- Tiantian Xue (ORCID: https://orcid.org/0000-0003-4776-9012)
- Mingqiang Li (ORCID: https://orcid.org/0000-0002-5178-4138)
- Yingying Xu (ORCID: https://orcid.org/0000-0003-4924-9379)
- Kai Li
- Yixin Zhang (ORCID: https://orcid.org/0000-0002-6669-4995)
- Haixia Wang (ORCID: https://orcid.org/0000-0002-5782-8242)
- Ke Yi (ORCID: https://orcid.org/0000-0003-2044-6870)
Publication Details
- Journal
- Advanced Science
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/advs.202470187
- Citations
- 1
- Primary Topic
- Advancements in Transdermal Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.21