Active Heme Metabolism Suppresses Macrophage Phagocytosis via the TLR4/Type I IFN Signaling/CD36 in Uterine Endometrial Cancer
Collectively, these findings elucidate that active heme metabolism of UECCs directly decreases phagocytosis by controlling the secretion of TLR4-mediated IFN Iα and the expression of CD36, and further contributing to the immune escape of UEC.
Authors
- Yi‐Xing Yang
- Feng Xie (ORCID: https://orcid.org/0000-0003-4867-6563)
- Jiajing Lu (ORCID: https://orcid.org/0000-0002-0827-0596)
- Ayitila Abudukeyoumu
- Ming‐Qing Li (ORCID: https://orcid.org/0000-0002-9276-0722)
- Hongwei Zhang (ORCID: https://orcid.org/0000-0001-6378-4883)
- Xing Zhang (ORCID: https://orcid.org/0000-0002-1466-3839)
- Ding‐Yu Hou
Institutions
- Jiading District Central Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- American Journal of Reproductive Immunology
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1111/aji.13916
- Citations
- 5
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- National Key Research and Development Program of China