Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood
Low-grade systemic inflammation peaking in midchildhood was associated with specific mental and cardiometabolic disorders in young adulthood. These findings suggest that low-grade persistent inflammation in early life may be an important shared common factor for mental-physical comorbidity and so could be relevant to future efforts of patient stratification and risk profiling.
Authors
- Benjamin I. Perry (ORCID: https://orcid.org/0000-0002-1533-026X)
- Edward Palmer (ORCID: https://orcid.org/0000-0002-3548-4282)
- Jack Rogers
- Rachel Upthegrove (ORCID: https://orcid.org/0000-0001-8204-5103)
- Steven Marwaha (ORCID: https://orcid.org/0000-0002-0303-9942)
- Ella Warwick
- Isabel Morales‐Muñoz (ORCID: https://orcid.org/0000-0002-4718-6768)
Institutions
- University of Cambridge (GB)
- Birmingham and Solihull Mental Health NHS Foundation Trust (GB)
- Centre for Mental Health (GB)
- Cambridgeshire and Peterborough NHS Foundation Trust (GB)
- Birmingham Women’s and Children’s NHS Foundation Trust (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- JAMA Psychiatry
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1001/jamapsychiatry.2024.2193
- Citations
- 29
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 9.13
Funders
- Medical Research Council