Pigment Epithelium-Derived Factor Binding to VEGFR-1 (Flt-1) Increases the Survival of Retinal Neurons
These results suggest that PEDF can target VEGFR-1/Flt-1 and this interaction plays a significant role in PEDF-mediated neuroprotection in the retina.
Authors
- Sven Rothemund
- Ruaa Younis
- Jan Darius Unterlauft (ORCID: https://orcid.org/0000-0003-1469-0412)
- Xiu Mei Yang (ORCID: https://orcid.org/0009-0003-3287-6904)
- Susanne Bürger
- Johannes Lange (ORCID: https://orcid.org/0000-0003-0604-4891)
- Oliver Scheer
- Heidi Kaastrup Müller (ORCID: https://orcid.org/0000-0002-9842-8114)
- Jie Meng
- Wolfram Eichler
Institutions
- Stavanger University Hospital (NO)
- University Hospital of Bern (CH)
- The Military General Hospital of Beijing PLA (CN)
- University Hospital Leipzig (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1167/iovs.65.10.27
- Citations
- 2
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.08
Funders
- Deutsche Forschungsgemeinschaft
- Universität Leipzig