Cholesterol Accumulation Promotes Photoreceptor Senescence and Retinal Degeneration
Cholesterol accumulation promotes cellular senescence in photoreceptors. Eliminating senescent photoreceptors improves visual function in a model of retinal neurodegeneration, and senotherapy offers a novel therapeutic avenue for further investigation.
Authors
- Tae Jun Lee (ORCID: https://orcid.org/0000-0003-2699-2573)
- Joseph B. Lin (ORCID: https://orcid.org/0000-0001-6667-9018)
- Taku Yamamoto (ORCID: https://orcid.org/0000-0001-7375-8021)
- Shinobu Yamaguchi (ORCID: https://orcid.org/0000-0001-9515-7622)
- Andrea Santeford (ORCID: https://orcid.org/0000-0002-7691-6213)
- Brian S. Sohn (ORCID: https://orcid.org/0000-0002-6532-1222)
- Ryo Terao (ORCID: https://orcid.org/0000-0001-6182-4343)
- Mitsukuni Yoshida (ORCID: https://orcid.org/0000-0002-2752-1231)
- Charles W. Pfeifer (ORCID: https://orcid.org/0000-0002-7579-2984)
- Rajendra S. Apte (ORCID: https://orcid.org/0000-0003-2281-2336)
- Jason Colasanti (ORCID: https://orcid.org/0000-0002-7151-0011)
Institutions
- Washington University in St. Louis (US)
- Hokkaido University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-08-21
- DOI
- https://doi.org/10.1167/iovs.65.10.29
- Citations
- 8
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- International Retinal Research Foundation
- Research to Prevent Blindness
- Washington University in St. Louis
- Carl Marshall and Mildred Almen Reeves Foundation
- VitreoRetinal Surgery Foundation
- National Institutes of Health
- University of California, Los Angeles
- McDonnell Center for Systems Neuroscience
- Washington University School of Medicine in St. Louis
- Japan Society for the Promotion of Science