HOCl-producing electrochemical bandage is active in murine polymicrobial wound infection
New approaches are needed to combat the rise of antimicrobial-resistant infections. The HOCl-producing electrochemical bandage (e-bandage) leverages <i>in situ</i> generation of HOCl, a natural biocide, for broad-spectrum killing of wound pathogens. Unlike traditional therapies that may exhibit limited activity against biofilms and antimicrobial-resistant organisms, the e-bandage offers a potent, standalone solution that does not contribute to further resistance or require adjunctive antibiotic therapy. Here, we show the ability of the e-bandage to address polymicrobial infection by antimicrobial resistant clinical isolates of <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>, two commonly isolated, co-infecting wound pathogens. Effectiveness of the HOCl-producing e-bandage in reducing pathogen load while minimizing tissue toxicity and avoiding the need for systemic antibiotics underscores its potential as a tool in managing complex wound infections.
Authors
- Melissa J. Karau (ORCID: https://orcid.org/0000-0001-6021-4033)
- Ibrahim Bozyel (ORCID: https://orcid.org/0000-0002-2841-7890)
- Suzanne Gelston
- Kerryl E. Greenwood‐Quaintance (ORCID: https://orcid.org/0000-0003-3760-4310)
- Haluk Beyenal (ORCID: https://orcid.org/0000-0003-3931-0244)
- Dilara Ozdemir (ORCID: https://orcid.org/0000-0003-1304-3053)
- Derek Fleming (ORCID: https://orcid.org/0000-0002-0054-904X)
- Robin Patel (ORCID: https://orcid.org/0000-0001-6344-4141)
- Md Monzurul Islam Anoy (ORCID: https://orcid.org/0000-0001-6876-2632)
- Audrey N. Schuetz (ORCID: https://orcid.org/0000-0002-5837-270X)
- Luz Cuello (ORCID: https://orcid.org/0009-0001-0000-9916)
- Christina A. Koscianski (ORCID: https://orcid.org/0009-0004-7320-5055)
- Jayawant N. Mandrekar (ORCID: https://orcid.org/0000-0002-9718-4082)
Institutions
- Mayo Clinic (US)
- Mayo Clinic in Florida (US)
- Washington State University (US)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1128/spectrum.00626-24
- Citations
- 3
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases