RESIST ACINETO test for the rapid detection of NDM and OXA acquired carbapenemases directly from blood culture in <i>Acinetobacter</i> species
The incidence of bloodstream infections with carbapenem-resistant <i>Acinetobacter baumannii</i> (CRAB) could be very high in some countries such as the Balkans or Southeast Asia. In case of positive blood cultures with Gram-negative bacteria, the use of the RESIST ACINETO test could prove highly beneficial for the rapid identification of these imipenem-resistant bacteria and their antibiotic resistance mechanisms. In addition, it is now well established that New-Delhi Metallo-beta-lactamase (NDM) carbapenemase-producing isolates can have increased MICs of cefiderocol, which is an alternative treatment for these infections. This test may also allow the optimization of treatment based on the type of carbapenemase present. Finally, the RESIST ACINETO test is a rapid, easy-to-use, and cost-effective assay that demonstrates excellent performance in detecting the major acquired carbapenemases present in the <i>Acinetobacter species</i>.
Authors
- Anaïs Potron (ORCID: https://orcid.org/0000-0002-2966-7947)
- Pierre‐Edouard Fournier (ORCID: https://orcid.org/0000-0001-8463-8885)
- Olivier Belmonte
- Guillaume Miltgen (ORCID: https://orcid.org/0000-0002-5178-9879)
- Thomas Garrigos (ORCID: https://orcid.org/0000-0003-4558-4532)
- Pauline Choulet
- Katy Jeannot (ORCID: https://orcid.org/0000-0002-4634-8550)
- Loïk Sababadichetty
- Mila Bay
- Marion Daniel
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Centre Hospitalier Universitaire de La Réunion (RE)
- Centre Hospitalier Universitaire de Besançon (FR)
- Processus Infectieux en Milieu Insulaire Tropical (RE)
- Institut de Recherche pour le Développement (FR)
- Université de Franche-Comté (FR)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1128/spectrum.01044-24
- Citations
- 6
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.02
Funders
- European Regional Development Fund