RESIST ACINETO test for the rapid detection of NDM and OXA acquired carbapenemases directly from blood culture in <i>Acinetobacter</i> species

The incidence of bloodstream infections with carbapenem-resistant <i>Acinetobacter baumannii</i> (CRAB) could be very high in some countries such as the Balkans or Southeast Asia. In case of positive blood cultures with Gram-negative bacteria, the use of the RESIST ACINETO test could prove highly beneficial for the rapid identification of these imipenem-resistant bacteria and their antibiotic resistance mechanisms. In addition, it is now well established that New-Delhi Metallo-beta-lactamase (NDM) carbapenemase-producing isolates can have increased MICs of cefiderocol, which is an alternative treatment for these infections. This test may also allow the optimization of treatment based on the type of carbapenemase present. Finally, the RESIST ACINETO test is a rapid, easy-to-use, and cost-effective assay that demonstrates excellent performance in detecting the major acquired carbapenemases present in the <i>Acinetobacter species</i>.

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Publication Details

Journal
Microbiology Spectrum
Published
2024-08-20
DOI
https://doi.org/10.1128/spectrum.01044-24
Citations
6
Primary Topic
Antibiotic Resistance in Bacteria
Type
article
Field-Weighted Citation Impact
1.02

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article

RESIST ACINETO test for the rapid detection of NDM and OXA acquired carbapenemases directly from blood culture in Acinetobacter species

Anaïs Potron, Pierre‐Edouard Fournier, Olivier Belmonte, Guillaume Miltgen et al.
6 citations
Microbiology Spectrum
Antibiotic Resistance in Bacteria
1.02
article

RESIST ACINETO test for the rapid detection of NDM and OXA acquired carbapenemases directly from blood culture in Acinetobacter species

Anaïs Potron, Pierre‐Edouard Fournier, Olivier Belmonte, Guillaume Miltgen, Thomas Garrigos, Pauline Choulet, Katy Jeannot, Loïk Sababadichetty, Mila Bay, Marion Daniel
article en
6 citations

Abstract

The incidence of bloodstream infections with carbapenem-resistant <i>Acinetobacter baumannii</i> (CRAB) could be very high in some countries such as the Balkans or Southeast Asia. In case of positive blood cultures with Gram-negative bacteria, the use of the RESIST ACINETO test could prove highly beneficial for the rapid identification of these imipenem-resistant bacteria and their antibiotic resistance mechanisms. In addition, it is now well established that New-Delhi Metallo-beta-lactamase (NDM) carbapenemase-producing isolates can have increased MICs of cefiderocol, which is an alternative treatment for these infections. This test may also allow the optimization of treatment based on the type of carbapenemase present. Finally, the RESIST ACINETO test is a rapid, easy-to-use, and cost-effective assay that demonstrates excellent performance in detecting the major acquired carbapenemases present in the <i>Acinetobacter species</i>.

Microbiology SpectrumVol. 12(10)
Centre National de la Recherche Scientifique (FR), Inserm (FR), Centre Hospitalier Universitaire de La Réunion (RE), Centre Hospitalier Universitaire de Besançon (FR), Processus Infectieux en Milieu Insulaire Tropical (RE), Institut de Recherche pour le Développement (FR), Université de Franche-Comté (FR)
European Regional Development Fund
Openalex Percentile: Top 27%
Antibiotic Resistance in Bacteria
1.02
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