Pharmacokinetic Factors Associated With Early Meropenem Target Attainment in Pediatric Severe Sepsis*
Eight of 29 pediatric patients with early severe sepsis did not meet the selected TA threshold within the first 24 hours of meropenem therapy. Higher clearance was associated with failure to meet targets. Identifying patients likely to have higher meropenem clearance could help with dosing regimens.
Authors
- Abigayle Gibson
- Tomoyuki Mizuno (ORCID: https://orcid.org/0000-0002-8471-9826)
- Peter Tang
- Kelli Paice (ORCID: https://orcid.org/0000-0003-0863-7316)
- Sonya Tang Girdwood (ORCID: https://orcid.org/0000-0001-7737-8499)
- Alexander A. Vinks (ORCID: https://orcid.org/0000-0003-4224-2967)
- Jennifer Kaplan (ORCID: https://orcid.org/0000-0001-7020-2394)
- Kathryn Pavia (ORCID: https://orcid.org/0000-0002-6231-3323)
- Rhonda M. Jones
- Nieko Punt (ORCID: https://orcid.org/0000-0002-7655-6094)
- Min Dong (ORCID: https://orcid.org/0000-0002-8552-8298)
- Calise Curry
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University Medical Center Groningen (NL)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Pediatric Critical Care Medicine
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1097/pcc.0000000000003599
- Citations
- 8
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 3.58
Funders
- Cincinnati Children's Hospital Medical Center
- Astellas Pharma
- National Institutes of Health
- Chugai Pharmaceutical
- National Institute of General Medical Sciences
- National Institute of Child Health and Human Development
- National Center for Advancing Translational Sciences