Areca nut-induced metabolic reprogramming and M2 differentiation promote OPMD malignant transformation
Our study provides novel mechanisms for areca nut-induced oral carcinogenesis, demonstrating that areca nut promotes M2 macrophage differentiation and secretion of oncogenic cytokines that critically activate malignant transformation of oral premalignant cells.
Authors
- Shigetaka Shimodaira (ORCID: https://orcid.org/0000-0002-6612-6912)
- Stephen Chu‐Sung Hu (ORCID: https://orcid.org/0000-0002-1832-4471)
- Changwei Su (ORCID: https://orcid.org/0000-0003-0435-6293)
- Leong‐Perng Chan (ORCID: https://orcid.org/0000-0001-8192-2725)
- Yen‐Yun Wang (ORCID: https://orcid.org/0000-0003-4442-4801)
- Steven Lo (ORCID: https://orcid.org/0000-0003-1503-1056)
- Shyng‐Shiou F. Yuan (ORCID: https://orcid.org/0000-0002-4753-788X)
- Jeff Yi-Fu Chen
- Yuk-Kwan Chen
- Hieu D.H. Nguyen
Institutions
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Medical University (TW)
- Kanazawa Medical University (JP)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Kanazawa Medical University Hospital (JP)
- Tokyo Women's Medical University (JP)
- Kaohsiung Municipal Ta-Tung Hospital (TW)
- Canniesburn Hospital (GB)
- University of Glasgow (GB)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1186/s13046-024-03163-z
- Citations
- 10
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.00
Funders
- Ministry of Education
- Kaohsiung Medical University
- Kaohsiung Medical University Chung-Ho Memorial Hospital
- National Science and Technology Council