Radiosynthesis and preclinical evaluation of a 68Ga-labeled tetrahydroisoquinoline-based ligand for PET imaging of C-X-C chemokine receptor type 4 in an animal model of glioblastoma
The newly developed CXCR4 PET tracer, [<sup>68</sup>Ga]Ga-TD-01, exhibited a high binding inhibition for CXCR4, excellent in vitro stability, and favorable pharmacokinetics, suggesting that the compound is a promising candidate for full in vivo characterization of CXCR4 expression in GBM, with potential for further development as a tool in cancer diagnosis.
Authors
- Piyapan Suwattananuruk
- Pranee Rojsitthisak (ORCID: https://orcid.org/0000-0002-4088-6542)
- Rodrigo Berzaghi
- Opa Vajragupta (ORCID: https://orcid.org/0000-0003-3313-0621)
- Dominique Schols (ORCID: https://orcid.org/0000-0003-3256-5850)
- Stine Figenschau
- Mathias Kranz (ORCID: https://orcid.org/0000-0002-5641-7396)
- Angel Moldes‐Anaya (ORCID: https://orcid.org/0000-0002-2338-5850)
- Sukanya Yaset
- Chanisa Chotipanich
- Rune Sundset
- Sandra Claes (ORCID: https://orcid.org/0000-0002-9255-9199)
Institutions
- University Hospital of North Norway (NO)
- Chulalongkorn University (TH)
- Chulabhorn Hospital (TH)
- UiT The Arctic University of Norway (NO)
- KU Leuven (BE)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1186/s41181-024-00290-y
- Citations
- 1
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.28
Funders
- Universitetet i Tromsø
- Trond Mohn stiftelse
- Chulalongkorn University
- National Research Council of Thailand
- Jiaxing University