Uveal Melanoma Zebrafish Xenograft Models Illustrate the Mutation Status-Dependent Effect of Compound Synergism or Antagonism
Perivitelline space inoculation provides robust zebrafish xenografts with the ability for high-throughput drug screening and robust data acquisition using Z-Tada. This model demonstrates that drug discovery for uveal melanoma must take mutational subclasses into account, especially in combinatorial treatment discoveries.
Authors
- Erwin Brosens (ORCID: https://orcid.org/0000-0001-8235-4010)
- Quincy C. C. van den Bosch (ORCID: https://orcid.org/0009-0009-3675-6006)
- Emine Kılıç (ORCID: https://orcid.org/0000-0002-6867-3792)
Institutions
- Erasmus MC Cancer Institute (NL)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1167/iovs.65.10.26
- Citations
- 5
- Primary Topic
- Zebrafish Biomedical Research Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Stichting voor Ooglijders