Inhibition of SARS-CoV-2 infection by <i>Porphyromonas gingivalis</i> and the oral microbiome
The oral microbiome is important in health and disease, and in this study, we addressed the potential role of the oral microbiome in COVID-19 infection. Our <i>in vitro</i> studies suggest that certain bacteria of the oral microbiome such as <i>P. gingivalis</i> produce compounds that could potentially inhibit SARS-CoV-2 infection. These findings elucidating the interactions between the oral microbiome and SARS-CoV-2 infection will be important in our understanding of COVID-19 pathogenesis and the development of innovative therapeutic and preventive strategies against COVID-19 infection.
Authors
- Sibel A. Antonson (ORCID: https://orcid.org/0000-0002-7916-9655)
- Maria Rita Pastore
- Alexandra Lugo (ORCID: https://orcid.org/0000-0001-8338-1395)
- Alexander Bontempo (ORCID: https://orcid.org/0000-0001-7628-9590)
- Alexandra Chirino (ORCID: https://orcid.org/0000-0002-5840-4986)
- Alireza Heidari (ORCID: https://orcid.org/0000-0003-2655-133X)
- Mary Ellen Davey (ORCID: https://orcid.org/0000-0001-8129-0537)
- Toshihisa Kawai (ORCID: https://orcid.org/0000-0003-3310-3818)
- Satoru Shindo (ORCID: https://orcid.org/0000-0003-0478-9363)
- Cristina Godoy (ORCID: https://orcid.org/0000-0001-5037-1916)
- Frank C. Nichols (ORCID: https://orcid.org/0000-0001-6800-1112)
- Mark J. Cayabyab (ORCID: https://orcid.org/0000-0002-7803-8098)
- Jan Potempa (ORCID: https://orcid.org/0000-0002-3600-7461)
- Riccardo Madonia
Institutions
- Jagiellonian University (PL)
- University of Connecticut (US)
- University of Louisville (US)
- Nova Southeastern University (US)
- Biruni University (TR)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1128/spectrum.00599-24
- Citations
- 5
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- Blue Cross and Blue Shield of Florida Foundation
- National Institutes of Health
- National Institute of General Medical Sciences
- National Institute of Dental and Craniofacial Research