Prolongation of the Time Window From Traumatic Limb Amputation to Replantation From 6 to 33 Hours Using Ex Vivo Limb Perfusion
The use of a 24-hour ECP has successfully extended limb preservation to 33 hours. The modified histidine-tryptophan-ketoglutarate perfusate demonstrated its ability for muscle protection. This innovative approach not only facilitates limb replantation after combat injuries, surmounting geographical barriers, but also broadens the prospects for well-matched limb allotransplants across countries and continents.
Authors
- Robert Rieben (ORCID: https://orcid.org/0000-0003-4179-8891)
- Ilaria Petruccione (ORCID: https://orcid.org/0000-0002-5424-0400)
- Simone de Brot (ORCID: https://orcid.org/0000-0003-3049-0103)
- Esther Voegelin
- Mariafrancesca Petrucci (ORCID: https://orcid.org/0000-0003-0768-7514)
- Ramin Ipaktchi
- Léna G. Dietrich (ORCID: https://orcid.org/0009-0000-2771-2604)
- Jane Shaw-Boden
- Alain Despont
- Kay Nettelbeck
- Alessandro Mirra (ORCID: https://orcid.org/0000-0002-5036-7500)
- Mitra Gultom (ORCID: https://orcid.org/0000-0003-0806-1636)
- Chiara Parodi (ORCID: https://orcid.org/0000-0002-2689-2049)
- Daniela Casoni (ORCID: https://orcid.org/0000-0001-8852-2134)
- Svenja Büttiker
- Bilal Ben Brahim
- Junhua Wang (ORCID: https://orcid.org/0000-0002-6110-3711)
- Isabel Arenas Hoyos (ORCID: https://orcid.org/0000-0002-3143-2784)
- Lei Zhang
- Hansjörg Jenni
- David Siegrist
- L.G. Garcia Casalta
Institutions
- University of Bern (CH)
- Bern University of Applied Sciences (CH)
- University Hospital of Bern (CH)
Publication Details
- Journal
- Military Medicine
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1093/milmed/usae043
- Citations
- 6
- Primary Topic
- Organ and Tissue Transplantation Research
- Type
- article
- Field-Weighted Citation Impact
- 3.05
Funders
- U.S. Department of Defense