Nosocomial transmission of fluconazole-resistant <i>Candida glabrata</i> bloodstream isolates revealed by whole-genome sequencing
The prevalence of fluconazole-resistant bloodstream infections caused by <i>Candida glabrata</i> is increasing globally, but the transmission of these resistant strains within hospitals has rarely been documented. Through whole-genome sequencing and epidemiological analyses, this study identified two potential clusters of <i>C. glabrata</i> bloodstream infections within the same hospital, revealing the transmission of clonal <i>C. glabrata</i> strains with different levels of fluconazole susceptibility or distinct transcription factor pleiotropic drug resistance protein 1 (Pdr1p) single-nucleotide polymorphism profiles among patients receiving antifungal therapy.
Authors
- Eun Jeong Won (ORCID: https://orcid.org/0000-0002-8750-4257)
- Jong Hee Shin (ORCID: https://orcid.org/0000-0001-9593-476X)
- Yong Jun Kwon (ORCID: https://orcid.org/0000-0001-9342-0570)
- Ha Jin Lim (ORCID: https://orcid.org/0000-0003-2436-5007)
- Dongeun Yong (ORCID: https://orcid.org/0000-0002-1225-8477)
- Hyukmin Lee (ORCID: https://orcid.org/0000-0002-8523-4126)
- Ga Yeong Lee
- Seung A. Byun (ORCID: https://orcid.org/0000-0003-4013-7274)
- Ki Ho Hong (ORCID: https://orcid.org/0000-0002-5700-9036)
- Soo Hyun Kim (ORCID: https://orcid.org/0000-0002-1293-1377)
- Eun Song Song (ORCID: https://orcid.org/0000-0001-5916-2651)
- In Ji Hwang
Institutions
- Ulsan College (KR)
- Yonsei University (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
- Chonnam National University Hospital (KR)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1128/spectrum.00883-24
- Citations
- 3
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Research Foundation
- National Research Foundation of Korea