Genetic and epigenetic regulation of cortactin (<i>CTTN</i>) by inflammatory factors and mechanical stress in human lung endothelial cells
CTTN transcriptional is significantly influenced by inflammatory factors and promoter variants. Cortactin, essential in mitigating inflammatory edema, presents a promising therapeutic target to alleviate severe inflammatory disorders.
Authors
- Xiaoguang Sun (ORCID: https://orcid.org/0000-0003-4226-8294)
- Donna D. Zhang (ORCID: https://orcid.org/0000-0002-8972-697X)
- Patrick Belvitch (ORCID: https://orcid.org/0000-0002-2404-8346)
- Christian Bime
- Sara M. Camp
- Joe G. N. Garcia (ORCID: https://orcid.org/0000-0002-6934-0420)
- Steven M. Dudek
- Belinda Sun (ORCID: https://orcid.org/0000-0002-0055-2206)
- Saad Sammani (ORCID: https://orcid.org/0000-0002-7933-6388)
Institutions
- Scripps Research Institute (US)
- University of Arizona (US)
- University of Florida (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- Jupiter Medical Center (US)
- Jupiter (United States) (US)
Publication Details
- Journal
- Bioscience Reports
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1042/bsr20231934
- Citations
- 3
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute