A Database Tool Integrating Genomic and Pharmacologic Data from Adrenocortical Carcinoma Cell Lines, PDX, and Patient Samples
ACC_CellMinerCDB, a comprehensive database of cell lines, patient-derived xenografts, surgical samples, and drug responses, reveals shared genomic pathways and treatment-relevant markers in ACC. This resource offers insights into potential therapeutic targets and the opportunity to repurpose existing drugs for ACC therapy.
Authors
- Alfredo Berruti (ORCID: https://orcid.org/0000-0002-3956-0043)
- Sudhir Varma (ORCID: https://orcid.org/0000-0002-4096-4782)
- Mariangela Tamburello (ORCID: https://orcid.org/0000-0001-7827-0025)
- Nitin Roper (ORCID: https://orcid.org/0000-0002-6514-5468)
- Craig J. Thomas (ORCID: https://orcid.org/0000-0001-9386-9001)
- Ukhyun Jo (ORCID: https://orcid.org/0000-0002-2826-1355)
- Fathi Elloumi (ORCID: https://orcid.org/0009-0007-7116-508X)
- Jaydira Del Rivero (ORCID: https://orcid.org/0000-0001-9710-4030)
- Suresh Kumar (ORCID: https://orcid.org/0000-0001-7404-8259)
- Michael M. Gottesman (ORCID: https://orcid.org/0000-0001-8908-2097)
- Katja Kiseljak‐Vassiliades (ORCID: https://orcid.org/0000-0003-3341-582X)
- Yasuhiro Arakawa (ORCID: https://orcid.org/0000-0003-1582-0282)
- Yves Pommier (ORCID: https://orcid.org/0000-0002-3108-0758)
- Andrea Abate (ORCID: https://orcid.org/0000-0002-0835-0916)
- Sandra Sigala (ORCID: https://orcid.org/0000-0003-3294-4121)
- Constanze Hantel (ORCID: https://orcid.org/0009-0000-8906-2563)
- Robert W. Robey (ORCID: https://orcid.org/0000-0002-0857-3650)
- Prashant Khandagale (ORCID: https://orcid.org/0000-0002-9751-2189)
- William C. Reinhold (ORCID: https://orcid.org/0000-0001-5513-9323)
- Valentina Boeva (ORCID: https://orcid.org/0000-0002-4382-7185)
- Margaret E. Wierman (ORCID: https://orcid.org/0000-0002-7634-1093)
- Isabel Weigand (ORCID: https://orcid.org/0000-0001-5873-8567)
- Naoko Takebe (ORCID: https://orcid.org/0000-0002-5790-4954)
Institutions
- National Institutes of Health (US)
- University of Zurich (CH)
- University of Würzburg (DE)
- ETH Zurich (CH)
- University Hospital of Zurich (CH)
- Universitätsklinikum Würzburg (DE)
- National Cancer Institute (US)
- Center for Cancer Research (US)
- University Hospital Carl Gustav Carus (DE)
- University of Colorado Anschutz Medical Campus (US)
- University of Brescia (IT)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0100
- Citations
- 3
- Primary Topic
- Adrenal and Paraganglionic Tumors
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Japanese Society of Clinical Pharmacology and Therapeutics
- Uniscientia Foundation
- National Institutes of Health
- National Cancer Institute