Considerations for practical use of tree-based scan statistics for signal detection using electronic healthcare data: a case study with insulin glargine
Differences in detected alerts between TBSS methods and between TBSS and disproportionality analysis of SRD are likely attributable to differences in data, comparator, and study design. Our results suggest that HFDS methods like TBSS applied to EHD may complement more traditional approaches such as disproportionality analysis of SRD to provide a more complete picture of product safety in the post-approval setting.
Authors
- Lockwood G. Taylor (ORCID: https://orcid.org/0000-0002-8996-6455)
- Marielle Duverne
- Sreenivas Thummisetti
- Juhaeri Juhaeri (ORCID: https://orcid.org/0000-0001-8235-8388)
- Marie‐Laure Kürzinger (ORCID: https://orcid.org/0000-0002-2606-776X)
- Ruben Hermans
- Shirin Enshaeifar (ORCID: https://orcid.org/0000-0001-6216-0622)
- Sandrine Colas
- Xinyu Li (ORCID: https://orcid.org/0000-0002-5908-6676)
- Bernadette Dwan
- Priyanka Chhikara
Institutions
- IQVIA (United Kingdom) (GB)
- Sanofi (France) (FR)
- Sanofi (Canada) (CA)
- IQVIA (United States) (US)
- Sanofi (United States) (US)
- Sanofi (India) (IN)
- IQ Solutions (US)
Publication Details
- Journal
- Expert Opinion on Drug Safety
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1080/14740338.2024.2393274
- Citations
- 1
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.35