Epigenome‐wide association study of prostate cancer in African American men identified differentially methylated genes
Several differentially methylated genes involved in immune-oncologic pathways associated with disease risk or aggressiveness were identified. In addition, 261 African American-specific differentially methylated genes related to the risk of PCa were identified. These results can shedlight on potential mechanisms contributing to PCa disparities in the African American Population.
Authors
- Carmen Ortiz Sanchez
- Jaime Matta (ORCID: https://orcid.org/0000-0001-6668-9021)
- James J. Mulé (ORCID: https://orcid.org/0000-0001-7354-0516)
- Clement K. Gwede (ORCID: https://orcid.org/0000-0003-1630-7333)
- Jasreman Dhillon (ORCID: https://orcid.org/0000-0001-6785-3487)
- Hui‐Yi Lin (ORCID: https://orcid.org/0000-0002-3307-5549)
- Anders Berglund (ORCID: https://orcid.org/0000-0002-0393-3530)
- Julie Dutil (ORCID: https://orcid.org/0000-0002-0313-6443)
- Kathryn Hughes Barry (ORCID: https://orcid.org/0000-0003-4661-0595)
- Gilberto Ruiz-Deyá
- Tamara Lotan
- Rana Falahat (ORCID: https://orcid.org/0000-0001-7489-3807)
- Kosj Yamoah (ORCID: https://orcid.org/0000-0001-9055-3538)
- Ratna Chakrabarti (ORCID: https://orcid.org/0000-0002-0261-8520)
- Jacob K. Kresovich (ORCID: https://orcid.org/0000-0002-9577-226X)
- Jong Y. Park (ORCID: https://orcid.org/0000-0002-6384-6447)
- Seung Joon Kim (ORCID: https://orcid.org/0000-0003-4836-8958)
- Steven A. Eschrich (ORCID: https://orcid.org/0000-0002-9833-2788)
- Ryan M. Putney (ORCID: https://orcid.org/0000-0002-0468-736X)
- Liang Wang (ORCID: https://orcid.org/0000-0002-5247-6727)
- Young‐Chul Kim (ORCID: https://orcid.org/0000-0001-9461-9514)
- Sungjune Kim
- Hyun Park
Institutions
- University of Central Florida (US)
- Louisiana State University (US)
- University of Maryland, Baltimore (US)
- Johns Hopkins University (US)
- Ponce Health Sciences University (PR)
- Jacksonville College (US)
- Moffitt Cancer Center (US)
- Mayo Clinic in Florida (US)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- U-M Rogel Cancer Center (US)
- Elizabeth City State University (US)
- Louisiana State University Health Sciences Center New Orleans (US)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/cam4.70044
- Citations
- 8
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- U.S. Department of Defense
- Florida Department of Health
- Division of Cancer Prevention, National Cancer Institute
- National Cancer Institute
- Common Fund
- DOD Prostate Cancer Research Program