Cu(II)/Base Synergistic Promoted [2 + 1 + 3] Cyclization of Cyclic Ketones with α,β-Unsaturated Aldehydes/Ketones and NH<sub>4</sub>I to Access Fused Pyridines
Herein, a practical three-component [2 + 1 + 3] cyclization of various cyclic ketones with α,β-unsaturated aldehydes/ketones and ammonium iodide (NH<sub>4</sub>I) to access highly functional fused pyridines has been developed. The features of this transformation include mild reaction conditions, readily available starting materials, and excellent chemoselectivity. This protocol is compatible with various functional groups, and the preliminary studies on the mechanism of the reaction are also provided.
Authors
- Renhua Qiu (ORCID: https://orcid.org/0000-0002-8423-9988)
- Peng Du (ORCID: https://orcid.org/0009-0002-6264-2554)
- Nobuaki Kambe (ORCID: https://orcid.org/0000-0002-2887-9489)
- Lu Hao (ORCID: https://orcid.org/0000-0003-2126-1499)
- Yifeng Ou
- Shuang‐Feng Yin (ORCID: https://orcid.org/0000-0001-9857-9804)
- Xinyu Li (ORCID: https://orcid.org/0000-0003-4526-2197)
Institutions
- Hunan University (CN)
- The University of Osaka (JP)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1021/acs.orglett.4c02628
- Citations
- 8
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- National Natural Science Foundation of China
- Recruitment Program of Global Experts