Emergence of a novel sequence type carbapenem-resistant hypervirulent <i>Klebsiella pneumoniae</i> ST6417 harboring <i>bla</i> <sub>NDM-5</sub> on the lncX3 plasmid
ST11 and its variants, which often exhibit drug resistance, represent popular clones of carbapenem-resistant hypervirulent <i>Klebsiella pneumoniae</i> (CR-hvKP) in China, often leading to high morbidity and mortality rates owing to their high virulence and robust drug resistance. Conversely, CR-hvKP, originating from the high-virulence sequence type ST23, remains rarely reported. In this study, we identified a novel ST6417 CR-hvKP strain derived from ST23, carrying <i>bla</i><sub>NDM-5</sub> on an IncX3 plasmid conferring resistance to carbapenems. In addition, we elucidate its virulence, resistance to drugs, and genetic characteristics. The discovery of ST6417 highlights the diverse pathways in the evolution of CR-hvKP, warranting increased attention.
Authors
- Xuefei Du (ORCID: https://orcid.org/0000-0001-8313-7464)
- Junnian Liu
- Lu Qiao (ORCID: https://orcid.org/0000-0002-5930-3132)
- Xinyu Zhang (ORCID: https://orcid.org/0000-0001-8154-9334)
- Yu Sun
- Luhan Xuan
- Sue Yuan
Institutions
- Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1128/spectrum.00984-24
- Citations
- 2
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- Sir Run Run Shaw Hospital
- Zhejiang University
- National Taiwan University Hospital