Unveiling the Potential of Bergenia Phenolics: Vitexin's Role in Allosteric Modulation of PBP2a as a Strategy against MRSA Resistance
It has been intriguing to observe a correlation between the affinity of the lead vitexin at the allosteric site and the modification of Tyr446, the active site gatekeeper residue in PBP2a. Our findings have implied that lead vitexin can either directly or indirectly decrease PBP2a activity by inducing allosteric site change in conventional medicine.
Authors
- Abhishek Verma (ORCID: https://orcid.org/0000-0001-5380-0026)
- Sandeep Kumar Srivastava (ORCID: https://orcid.org/0000-0002-7138-1387)
- Anshulika Saxena
Institutions
- Manipal University Jaipur
Publication Details
- Journal
- Current Topics in Medicinal Chemistry
- Published
- 2024-08-20
- DOI
- https://doi.org/10.2174/0115680266312143240805191718
- Citations
- 3
- Primary Topic
- Phytochemistry and Bioactivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.40