Three prolonged outbreaks of metallo-β-lactamase-producing <i>Pseudomonas aeruginosa</i> in an Upper Austrian hospital, 2017–2023

The significance of our work lies in the successful resolution of three prolonged outbreaks of MBL-Pa infections in a hospital in Upper Austria. Through a comprehensive epidemiological investigation coupled with WGS-based typing of <i>P. aeruginosa</i> isolates, the study identified three distinct genomic clusters responsible for prolonged outbreaks involving 47 cases. The investigation pinpointed sinks in the ICU washroom as the likely source of infection for two of the clusters. The study demonstrates the effectiveness of control measures such as hand hygiene, gowning, patient isolation, screening, and disinfection in stopping further transmission and bringing the outbreaks to a close. This underscores the critical role of genomic surveillance and control measures, particularly in high-risk settings like ICUs, in reducing nosocomial transmission of MBL-Pa infections.

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Publication Details

Journal
Microbiology Spectrum
Published
2024-08-20
DOI
https://doi.org/10.1128/spectrum.00740-24
Citations
2
Primary Topic
Antibiotic Resistance in Bacteria
Type
article
Field-Weighted Citation Impact
0.34

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article

Three prolonged outbreaks of metallo-β-lactamase-producing Pseudomonas aeruginosa in an Upper Austrian hospital, 2017–2023

Burkhard Springer, Patrick Hyden, Stefan Bletz, Beatriz Daza Prieto et al.
2 citations
Microbiology Spectrum
Antibiotic Resistance in Bacteria
0.34
article

Three prolonged outbreaks of metallo-β-lactamase-producing Pseudomonas aeruginosa in an Upper Austrian hospital, 2017–2023

Burkhard Springer, Patrick Hyden, Stefan Bletz, Beatriz Daza Prieto, Rick Conzemius, Adriana Cabal Rosel, Johannes Weinberger, Alexander Mellmann, Markus Hell, Anna Stöger, Kathrin Lippert, Werner Ruppitsch, Rainer Hartl, Sandra Köberl-Jelovcan, Anna Hörtenhuber, Yarub Salaheddin, Georg Steindl
article en
2 citations

Abstract

The significance of our work lies in the successful resolution of three prolonged outbreaks of MBL-Pa infections in a hospital in Upper Austria. Through a comprehensive epidemiological investigation coupled with WGS-based typing of <i>P. aeruginosa</i> isolates, the study identified three distinct genomic clusters responsible for prolonged outbreaks involving 47 cases. The investigation pinpointed sinks in the ICU washroom as the likely source of infection for two of the clusters. The study demonstrates the effectiveness of control measures such as hand hygiene, gowning, patient isolation, screening, and disinfection in stopping further transmission and bringing the outbreaks to a close. This underscores the critical role of genomic surveillance and control measures, particularly in high-risk settings like ICUs, in reducing nosocomial transmission of MBL-Pa infections.

Microbiology SpectrumVol. 12(10)
Johannes Kepler University of Linz (AT), Paracelsus Medical University (AT), University Hospital Münster (DE), Engineering Software Steyr (Austria) (AT), Krankenhaus der Elisabethinen (AT), Austrian Agency for Health and Food Safety (AT)
European Commission
Zero hunger
Openalex Percentile: Top 48%
Antibiotic Resistance in Bacteria
0.34
DOIOpen Access PDFOpenAlex
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