Chemotherapy Drives Tertiary Lymphoid Structures That Correlate with ICI-Responsive TCF1+CD8+ T Cells in Metastatic Ovarian Cancer
Altogether, our findings suggest that NACT promotes TLS formation and maturation in HGSOC lesions, de facto preserving an intratumoral ICI-sensitive T-cell phenotype. These observations emphasize the role of rational design, especially relative to the administration schedule, for clinical trials testing chemotherapy plus ICIs in patients with HGSOC. See related commentary by Bravo Melgar and Laoui, p. 10.
Authors
- Lenka Kašíková (ORCID: https://orcid.org/0000-0002-4604-4821)
- Radek Špíšek
- Kateřina Mojžíšová
- Ann Vankerckhoven (ORCID: https://orcid.org/0000-0001-6289-444X)
- Petr Škapa (ORCID: https://orcid.org/0000-0002-7722-3718)
- Hannah Griebler
- Ján Laco (ORCID: https://orcid.org/0000-0002-9602-7501)
- Ivan Práznovec (ORCID: https://orcid.org/0000-0003-3878-9417)
- Tereza Láníčková
- Roman Kocián (ORCID: https://orcid.org/0000-0002-5896-4158)
- Francis Jacob (ORCID: https://orcid.org/0000-0002-0446-1942)
- Jitka Fučíková (ORCID: https://orcid.org/0000-0002-8423-479X)
- Marek Kovář (ORCID: https://orcid.org/0000-0002-6602-1678)
- Lukáš Rob (ORCID: https://orcid.org/0000-0003-3770-651X)
- Josef Pasulka (ORCID: https://orcid.org/0000-0001-6190-0465)
- An Coosemans (ORCID: https://orcid.org/0000-0002-7321-4339)
- Lorenzo Galluzzi (ORCID: https://orcid.org/0000-0003-2257-8500)
- David Cibula (ORCID: https://orcid.org/0000-0001-6387-9356)
- Sandra Oršulić (ORCID: https://orcid.org/0000-0001-5119-8721)
- Tomáš Brtnický (ORCID: https://orcid.org/0000-0002-6204-1903)
- Jana Drozenová (ORCID: https://orcid.org/0009-0005-5695-1221)
- Pavel Dundr (ORCID: https://orcid.org/0000-0002-8940-6124)
- Iain A. McNeish (ORCID: https://orcid.org/0000-0002-9387-7586)
- Michal Hensler (ORCID: https://orcid.org/0000-0002-8767-0722)
- Artemis Angelidou
- Ales Ryska
- Michal J. Halaska
Institutions
- Cedars-Sinai Medical Center (US)
- University of California, Los Angeles (US)
- University of Basel (CH)
- Czech Academy of Sciences (CZ)
- Cornell University (US)
- Charles University (CZ)
- Rega Institute for Medical Research (BE)
- University Hospital of Basel (CH)
- Lander Institute (IL)
- Generi Biotech (Czechia) (CZ)
- VIB-KU Leuven Center for Cancer Biology (BE)
- Ovarian Cancer Action (GB)
- University Hospital in Motol (CZ)
- Institute of Microbiology (BY)
- CancerCare (US)
- Sotio (Czechia) (CZ)
- Czech Academy of Sciences, Institute of Microbiology (CZ)
- Department of Biomedicine Basel (CH)
- University Hospital Hradec Králové (CZ)
- University Hospital Kralovske Vinohrady (CZ)
- VA Greater Los Angeles Healthcare System (US)
- General University Hospital in Prague (CZ)
- Imperial College London (GB)
- KU Leuven (BE)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-1594
- Citations
- 19
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 4.57