Intradermal Delivery of Calcium Hydroxylapatite With Fractionated Ablation
This observational pilot study demonstrates that CaHA, a collagen stimulator used as a dermal filler, can not only be inserted into the dermis after fractional laser treatment but remains in the healing skin for at least 6 weeks posttreatment. The noninvasive imaging techniques RCM and MPM successfully captured the presence of CaHA microspheres mid-dermis during the healing phase. They also demonstrated new collagen production around the microspheres, highlighting the effectiveness of these imaging approaches in monitoring such treatment over time.
Authors
- Mihaela Balu (ORCID: https://orcid.org/0000-0002-8018-5134)
- Alexander Vallmitjana (ORCID: https://orcid.org/0000-0002-7149-9385)
- Christopher B. Zachary (ORCID: https://orcid.org/0000-0002-5883-5188)
- Amanda Durkin (ORCID: https://orcid.org/0000-0002-7959-0044)
- Nicole M. Golbari (ORCID: https://orcid.org/0000-0002-9542-1910)
- William Driscoll
Institutions
- University of California, Irvine (US)
- Beckman Laser Institute and Medical Clinic (US)
Publication Details
- Journal
- Lasers in Surgery and Medicine
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1002/lsm.23830
- Citations
- 1
- Primary Topic
- Dermatologic Treatments and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.53
Funders
- University of California, Irvine
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institute of Biomedical Imaging and Bioengineering