COVID-19 throughout pandemic waves and virus variants: a real-life experience in an Italian hospital
New therapies and vaccines changed the management of COVID-19. The aim of this retrospective study was to describe characteristics, in-hospital mortality and its predictors in patients with moderate/severe COVID-19, considering the 4 different pandemic waves and viral variants' prevalence from February 2020 to January 2022. Among 1135 patients included, 873 (77%) had at least one comorbidity, 177 (16%) were immunocompromised. From waves 1 to 4, patients with severe respiratory failure and ICU admission decreased over time (<i>p</i> < 0.001), like the length of in-hospital stay (<i>p</i> < 0.001). Despite a reduction of in-hospital mortality from 19% to 11%, increased risk of death was related to older age and immunocompromising conditions, especially during the 4th wave (HR = 5.07 and HR = 10.86, <i>p</i> < 0.001 respectively) while remdesivir treatment in the 3rd wave (HR = 0.41, <i>p</i> = 0.010) and positive serology (aHR = 0.66, <i>p</i> = 0.027) were protective for survival. These data support the need for tailoring vaccine campaign for future COVID-19 waves.
Authors
- Federica Portunato (ORCID: https://orcid.org/0000-0003-3335-7586)
- Chiara Sepulcri (ORCID: https://orcid.org/0000-0003-1761-436X)
- Antonio Di Biagio (ORCID: https://orcid.org/0000-0003-1436-5089)
- Federica Magnè
- Laura Magnasco (ORCID: https://orcid.org/0000-0002-6343-3271)
- Silvia Dettori
- Giorgia Brucci (ORCID: https://orcid.org/0000-0002-9554-2210)
- Bianca Bruzzone (ORCID: https://orcid.org/0000-0002-3456-1899)
- Emanuele Delfino (ORCID: https://orcid.org/0000-0002-2973-5719)
- Chiara Dentone (ORCID: https://orcid.org/0000-0002-9096-5812)
- Małgorzata Mikulska (ORCID: https://orcid.org/0000-0002-5535-4602)
- Alessio Signori (ORCID: https://orcid.org/0000-0001-6289-9144)
- Matteo Bassetti (ORCID: https://orcid.org/0000-0002-0145-9740)
- Mauro Giacomini (ORCID: https://orcid.org/0000-0001-5646-2034)
- Sara Mora (ORCID: https://orcid.org/0000-0002-0613-3248)
- Elisa Balletto (ORCID: https://orcid.org/0000-0001-9716-5538)
- Lorenzo Ball (ORCID: https://orcid.org/0000-0002-3876-4730)
- Michele Mirabella (ORCID: https://orcid.org/0000-0002-6343-3343)
- Daniele Roberto Giacobbe (ORCID: https://orcid.org/0000-0003-2385-1759)
- Antonio Vena (ORCID: https://orcid.org/0000-0002-0697-3992)
- Marta Ponzano (ORCID: https://orcid.org/0000-0003-4091-4686)
- Cristina Marelli (ORCID: https://orcid.org/0000-0003-1510-1819)
Institutions
- Department of Health (TW)
- Ospedale Policlinico San Martino (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Journal of Chemotherapy
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1080/1120009x.2024.2384321
- Citations
- 1
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.39