Pre-existing cell subpopulations in primary prostate cancer tumors display surface fingerprints of docetaxel-resistant cells
In summary, we demonstrate that the identified 6-molecule surface fingerprint associated with docetaxel resistance pre-exists in a subpopulation of primary PCa tumors before docetaxel treatment. Thus, this fingerprint warrants further validation as a promising predictive tool for docetaxel resistance in PCa patients prior to therapy initiation.
Authors
- Jan Bouchal (ORCID: https://orcid.org/0000-0003-4842-1720)
- Zoran Čulig (ORCID: https://orcid.org/0000-0002-5001-6153)
- Wytske M. van Weerden (ORCID: https://orcid.org/0000-0003-0324-4804)
- Anna Kotrbová (ORCID: https://orcid.org/0000-0002-8094-4129)
- Vladimír Študent (ORCID: https://orcid.org/0000-0002-4983-1871)
- Kristína Gömöryová (ORCID: https://orcid.org/0000-0003-4407-3917)
- Vendula Pospíchalová (ORCID: https://orcid.org/0000-0002-5957-2156)
- Daniela Kurfürstová (ORCID: https://orcid.org/0000-0002-3175-3131)
- Eva Slabáková (ORCID: https://orcid.org/0000-0002-2416-4064)
- Radek Fedr
- Martin Eliáš (ORCID: https://orcid.org/0000-0003-0516-834X)
- Vı́tězslav Bryja (ORCID: https://orcid.org/0000-0002-9136-5085)
- Barbora Kvokačková (ORCID: https://orcid.org/0000-0002-6478-9923)
- Martin Puhr (ORCID: https://orcid.org/0000-0002-3858-9653)
- Karel Souček (ORCID: https://orcid.org/0000-0001-7283-8150)
- Stanislav Drápela (ORCID: https://orcid.org/0000-0002-9421-9972)
- Frederika Lenčéšová
- Ganji Sri Ranjani
Institutions
- Central European Institute of Technology (CZ)
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- Czech Academy of Sciences (CZ)
- Masaryk University (CZ)
- Erasmus MC (NL)
- Moffitt Cancer Center (US)
- Czech Academy of Sciences, Institute of Biophysics (CZ)
- Central European Institute of Technology – Masaryk University (CZ)
- University Hospital Brno (CZ)
- University Hospital Olomouc (CZ)
- International Clinical Research Center, St. Anne's University Hospital Brno (CZ)
- St. Anne's University Hospital Brno (CZ)
- Institute of Molecular and Translational Medicine (CZ)
- Erasmus MC Cancer Institute (NL)
- Palacký University Olomouc (CZ)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1007/s13402-024-00982-2
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Biofyzikální Ústav, Akademie Věd České Republiky