Design, Synthesis, and Biological Evaluation of Quinoline (Quinolinone) Derivatives as <scp>NADPH</scp> Oxidase (<scp>NOX</scp>) Inhibitors
NADPH oxidases (NOXs) are the sole enzyme in the human body that can directly produce reactive oxygen species. Recent studies have shown that NOXs is a very promising target for the treatment of diabetic nephropathy (DN). Here, a series of quinoline(quinolinone) derivatives have been designed based on pharmacophore strategy, synthesized and evaluated. Among them, 19d exhibits potent antiproliferative and NOXs inhibitory activities, and is worthy for further investigation.
Authors
- Xin-liang Yang
- Rui Yi (ORCID: https://orcid.org/0000-0002-1072-2627)
- Qianbin Li (ORCID: https://orcid.org/0000-0003-4522-3067)
- Gaoyun Hu
- Siming Wu
- Zhuo Chen (ORCID: https://orcid.org/0000-0002-5434-5747)
- Lei Zhang (ORCID: https://orcid.org/0000-0001-7438-0489)
Institutions
- Central South University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
- Yueyang Hospital (CN)
Publication Details
- Journal
- Chemical Biology & Drug Design
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1111/cbdd.14610
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- National Natural Science Foundation of China
- Central South University
- Natural Science Foundation of Hunan Province