Immunomodulators in patients receiving extracorporeal membrane oxygenation for COVID-19: a propensity-score adjusted analysis of the ELSO registry
In this cohort study, we found that immunomodulators, in particular corticosteroids, were associated with significantly higher mortality amongst patients receiving ECMO for COVID-19, after adjusting for potential confounding variables and propensity score. In addition, patients receiving corticosteroids with or without other immunomodulators had longer ECMO runs, which has potential implications for resource allocation. While residual confounding likely remains, further studies are required to evaluate the timing of immunomodulators and better understand the possible mechanisms behind this association, including secondary infections.
Authors
- Kiran Shekar (ORCID: https://orcid.org/0000-0002-1239-7514)
- Liang Shen (ORCID: https://orcid.org/0000-0001-7976-668X)
- Daniel Brodie (ORCID: https://orcid.org/0000-0002-0813-3145)
- Graeme MacLaren (ORCID: https://orcid.org/0000-0002-1307-4274)
- Ryan P. Barbaro (ORCID: https://orcid.org/0000-0002-3645-0359)
- Ryan Ruiyang Ling (ORCID: https://orcid.org/0000-0002-8335-7640)
- Kollengode Ramanathan
Institutions
- Bond University (AU)
- Johns Hopkins University (US)
- Queensland University of Technology (AU)
- The University of Queensland (AU)
- National University of Singapore (SG)
- University of Michigan (US)
- Johns Hopkins Medicine (US)
- National University Heart Centre Singapore (SG)
- Prince Charles Hospital (AU)
- National University Hospital (SG)
- National University Health System (SG)
Publication Details
- Journal
- Annals of Intensive Care
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1186/s13613-024-01368-1
- Citations
- 4
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 0.74