Novel Drp1 GTPase Inhibitor, Drpitor1a: Efficacy in Pulmonary Hypertension
Drpitor1a is a specific Drp1 GTPase inhibitor that reduces mitochondrial fission in PAH hPASMC and PAH BOEC. Drpitor1a reduces proliferation and induces apoptosis in PAH hPASMC and regresses monocrotaline-PAH. Drp1 is a therapeutic target in PAH, and Drpitor1a is a potential therapy with an interesting therapeutic sexual dimorphism.
Authors
- Luka Jedlovčnik (ORCID: https://orcid.org/0000-0002-9879-2573)
- Pierce Colpman
- Ashley Martin (ORCID: https://orcid.org/0009-0005-8170-1638)
- Mark L. Ormiston (ORCID: https://orcid.org/0000-0003-0907-1940)
- Jeffrey Mewburn (ORCID: https://orcid.org/0000-0002-1365-4228)
- Gopinath Sutendra (ORCID: https://orcid.org/0000-0002-8181-1483)
- Stephen L. Archer (ORCID: https://orcid.org/0000-0003-1106-3202)
- Patrícia Lima (ORCID: https://orcid.org/0000-0002-6456-2470)
- Michael R. Wells (ORCID: https://orcid.org/0009-0005-4667-8436)
- Kuang‐Hueih Chen
- Ruaa Al‐Qazazi (ORCID: https://orcid.org/0000-0003-0983-9745)
- Nolan M. Breault
- M. Martin VandenBroek (ORCID: https://orcid.org/0000-0003-4937-2502)
- Oliver W. Jones (ORCID: https://orcid.org/0009-0008-6398-2052)
- R. E. Bentley (ORCID: https://orcid.org/0000-0003-0486-8467)
- Isaac Emon (ORCID: https://orcid.org/0009-0002-6375-1074)
- V. Siddartha Yerramilli (ORCID: https://orcid.org/0000-0002-4562-682X)
- Elahe Alizadeh (ORCID: https://orcid.org/0000-0003-4046-1226)
- Yuan Zhao (ORCID: https://orcid.org/0000-0002-6123-8579)
- Danchen Wu (ORCID: https://orcid.org/0000-0003-3901-5907)
- Ross D. Jansen‐van Vuuren (ORCID: https://orcid.org/0000-0002-2919-6962)
- Asish Dasgupta (ORCID: https://orcid.org/0000-0002-3670-1197)
Institutions
- University of Ljubljana (SI)
- University of Alberta (CA)
- Queen's University (CA)
Publication Details
- Journal
- Hypertension
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1161/hypertensionaha.124.22822
- Citations
- 15
- Primary Topic
- ATP Synthase and ATPases Research
- Type
- article
- Field-Weighted Citation Impact
- 3.51
Funders
- Queen's University
- National Institutes of Health
- Canadian Institutes of Health Research