Screening and Identification of Natural Compounds as Potential Inhibitors of Glutamate Racemase, an Emerging Drug Target of Food Pathogen E. coli O157:H7: An In-silico Approach to Combat Increasing Drug Resistance
In summary, this study highlights the urgent need for alternative therapies against food-pathogenic <i>E. coli</i>, focusing on <i>E. coli</i> O157:H7. Evaluation of Glutamate Racemase as a drug target identified Frigocyclinone and Deslanoside as promising inhibitors. MD simulations indicated their stability, suggesting their potential as lead molecules for further research and treatment development.
Authors
- Uma Chaudhry (ORCID: https://orcid.org/0000-0002-0897-2926)
- Pandey Archna (ORCID: https://orcid.org/0000-0003-1323-9574)
- Anoushka Khanna (ORCID: https://orcid.org/0000-0001-6601-8762)
- Sujata Adhana (ORCID: https://orcid.org/0000-0003-4866-0115)
- Sibasis Sahoo (ORCID: https://orcid.org/0000-0002-6998-0911)
- Muniba Faiza (ORCID: https://orcid.org/0000-0003-4711-4075)
- Renu Baweja (ORCID: https://orcid.org/0000-0001-9868-2449)
- Rajnish Kumar (ORCID: https://orcid.org/0000-0001-5330-5703)
- Avneesh Mittal (ORCID: https://orcid.org/0000-0002-5819-4392)
- Samarth Gupta (ORCID: https://orcid.org/0000-0003-0734-0123)
Institutions
- University of Delhi (IN)
- Shivaji University (IN)
- International Centre for Genetic Engineering and Biotechnology (IN)
- Nazarbayev University (KZ)
Publication Details
- Journal
- Infectious Disorders - Drug Targets
- Published
- 2024-08-20
- DOI
- https://doi.org/10.2174/0118715265306131240809095241
- Citations
- 2
- Primary Topic
- Probiotics and Fermented Foods
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Indian Council of Medical Research