Metformin Radiosensitizing Effect on Hypoxic Oral Squamous Cell Carcinoma Cells by <scp>GAPDH</scp> and <scp>TAGLN2</scp>
This study suggests that metformin can enhance radiosensitivity in hypoxic cells, operating through modulation of GAPDH and TAGLN2. Furthermore, metformin effectively reduces mutated p53 levels in radiated cells under hypoxic conditions.
Authors
- Sérgio Henrique Sousa Santos (ORCID: https://orcid.org/0000-0002-7788-5447)
- Lucyana Conceição Farias (ORCID: https://orcid.org/0000-0002-5379-361X)
- Talita Antunes Guimarães (ORCID: https://orcid.org/0000-0002-6627-9919)
- Eliane Macedo Sobrinho Santos (ORCID: https://orcid.org/0000-0002-1576-4957)
- Alfredo Maurício Batista de Paula (ORCID: https://orcid.org/0000-0002-8715-0030)
- Marcos Flávio Silveira Vasconcelos D’Ângelo (ORCID: https://orcid.org/0000-0001-5754-3397)
- Sabrina Ferreira de Jesus
- André Luiz Sena Guimarães (ORCID: https://orcid.org/0000-0002-3162-3206)
- Marcela Gonçalves de Souza (ORCID: https://orcid.org/0000-0002-3337-9112)
- Eloá Mangabeira Santos
- Pericles Crisostomo de Souza
- Luiza Santiago
Institutions
- Universidade Federal de Minas Gerais (BR)
- Instituto Federal de Educação Ciência e Tecnologia do Norte de Minas Gerais (BR)
- Universidade Estadual de Montes Claros (BR)
Publication Details
- Journal
- Journal of Oral Pathology and Medicine
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1111/jop.13576
- Citations
- 2
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Laboratório Nacional de Biociências