A human brain atlas of <i>χ</i>‐separation for normative iron and myelin distributions
Iron and myelin are primary susceptibility sources in the human brain. These substances are essential for a healthy brain, and their abnormalities are often related to various neurological disorders. Recently, an advanced susceptibility mapping technique, which is referred to as χ-separation (pronounced as "chi"-separation), has been proposed, successfully disentangling paramagnetic iron from diamagnetic myelin. This method provided a new opportunity for generating high-resolution iron and myelin maps of the brain. Utilizing this technique, this study constructs a normative χ-separation atlas from 106 healthy human brains. The resulting atlas provides detailed anatomical structures associated with the distributions of iron and myelin, clearly delineating subcortical nuclei, thalamic nuclei, and white matter fiber bundles. Additionally, susceptibility values in a number of regions of interest are reported along with age-dependent changes. This atlas may have direct applications such as localization of subcortical structures for deep brain stimulation or high-intensity focused ultrasound and also serve as a valuable resource for future research.
Authors
- Kyung Won Chang (ORCID: https://orcid.org/0000-0002-8697-1195)
- Phil Hyu Lee (ORCID: https://orcid.org/0000-0001-9931-8462)
- Minjun Kim (ORCID: https://orcid.org/0000-0003-2104-4734)
- Chae Jung Park (ORCID: https://orcid.org/0000-0002-5567-8658)
- Kyeongseon Min (ORCID: https://orcid.org/0000-0001-7614-2089)
- Beomseok Sohn (ORCID: https://orcid.org/0000-0002-6765-8056)
- Na‐Young Shin (ORCID: https://orcid.org/0000-0003-1157-6366)
- Woo Jung Kim (ORCID: https://orcid.org/0000-0002-4963-4819)
- Hyeong‐Geol Shin (ORCID: https://orcid.org/0000-0001-7876-173X)
- Soohwa Song (ORCID: https://orcid.org/0000-0002-4723-5603)
- Jongho Lee (ORCID: https://orcid.org/0000-0002-9485-5434)
- Dong Hoon Shin (ORCID: https://orcid.org/0000-0002-3513-6333)
Institutions
- Kennedy Krieger Institute (US)
- Seoul National University (KR)
- Johns Hopkins University (US)
- Yonsei University (KR)
- Johns Hopkins Medicine (US)
- Severance Hospital (KR)
- Samsung Medical Center (KR)
- Institute of Behavioral Sciences (JP)
- Korea District Heating Corporation (KR)
- Gangnam Severance Hospital (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- NMR in Biomedicine
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1002/nbm.5226
- Citations
- 10
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 4.04
Funders
- Johns Hopkins University
- National Research Foundation
- Seoul National University
- National Research Foundation of Korea
- Institute of Engineering Research, Seoul National University