Muscle Tissue Transcriptome of Idiopathic Inflammatory Myopathy Reflects the Muscle Damage Process by Monocytes and Presence of Skin Lesions
Our study highlights a significant involvement of monocytes in muscle damage and delineates pathologic differences among IIM subtypes. DM was characterized by complement and interferon-α and γ signaling, whereas ARS-DM was associated with OXPHOS. Distinctive gene expression variations in muscle specimens suggest that different pathologic mechanisms underlie muscle damage in each IIM phenotype.
Authors
- Toshihiko Komai (ORCID: https://orcid.org/0000-0001-5890-3606)
- Tomohisa Okamura (ORCID: https://orcid.org/0000-0001-7257-5557)
- Akari Suzuki (ORCID: https://orcid.org/0000-0002-5343-3681)
- Shinsuke Yasuda (ORCID: https://orcid.org/0000-0001-6171-2077)
- Tsuneyo Mimori (ORCID: https://orcid.org/0000-0003-0016-2053)
- Yuichiro Fujieda (ORCID: https://orcid.org/0000-0003-4705-341X)
- Natsuka Umezawa (ORCID: https://orcid.org/0000-0001-6878-1884)
- Keita Ninagawa (ORCID: https://orcid.org/0000-0001-8082-1009)
- Fumitaka Mizoguchi (ORCID: https://orcid.org/0000-0002-3956-7122)
- Yusuke Sugimori (ORCID: https://orcid.org/0000-0001-7549-6491)
- Eiryo Kawakami (ORCID: https://orcid.org/0000-0001-9955-4342)
- Katsuya Suzuki (ORCID: https://orcid.org/0009-0008-2930-5365)
- Shinji Izuka (ORCID: https://orcid.org/0000-0002-9724-4911)
- Yuta Kochi (ORCID: https://orcid.org/0000-0002-8012-5078)
- Keishi Fujio (ORCID: https://orcid.org/0000-0001-7276-5254)
- Tatsuya Atsumi (ORCID: https://orcid.org/0000-0001-5657-962X)
- Koichiro Ohmura (ORCID: https://orcid.org/0000-0003-2927-9159)
- Tsutomu Takeuchi (ORCID: https://orcid.org/0000-0003-1111-8218)
- Takeshi Iwasaki (ORCID: https://orcid.org/0000-0002-9326-3699)
- Kazuhiko Yamamoto (ORCID: https://orcid.org/0000-0003-0529-4055)
- Naoki Kimura (ORCID: https://orcid.org/0000-0001-6642-7283)
- Mineto Ota (ORCID: https://orcid.org/0000-0003-4552-8573)
Institutions
- Tokyo Medical and Dental University (JP)
- Tokyo Medical University (JP)
- Keio University (JP)
- Hokkaido University (JP)
- Kyoto University (JP)
- RIKEN (JP)
- Institute for Rheumatic Diseases (Japan) (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- Takeda (Japan) (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-08-20
- DOI
- https://doi.org/10.1002/art.42972
- Citations
- 9
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 3.48
Funders
- Japan Agency for Medical Research and Development