ALM Resuscitation With Brain and Multiorgan Protection for Far-Forward Operations: Survival at Hypotensive Pressures

In rat and pig models of NCTH, small-volume ALM therapy resuscitates at hypotensive pressures by increasing CO and reducing SVR. This strategy is associated with heart and brain protection and maintained tissue O2 delivery. Translational studies are required to determine reproducibility and optimal component dosing. ALM therapy may find wide utility in prehospital and far-forward military environments.

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Publication Details

Journal
Military Medicine
Published
2024-08-19
DOI
https://doi.org/10.1093/milmed/usae090
Citations
4
Primary Topic
Trauma, Hemostasis, Coagulopathy, Resuscitation
Type
article
Field-Weighted Citation Impact
1.69
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article

ALM Resuscitation With Brain and Multiorgan Protection for Far-Forward Operations: Survival at Hypotensive Pressures

Jodie L. Morris, Geoffrey P. Dobson, Hayley L. Letson
4 citations
Military Medicine
Trauma, Hemostasis, Coagulopathy, Resuscitation
1.69
article

ALM Resuscitation With Brain and Multiorgan Protection for Far-Forward Operations: Survival at Hypotensive Pressures

Jodie L. Morris, Geoffrey P. Dobson, Hayley L. Letson
article en
4 citations

Abstract

In rat and pig models of NCTH, small-volume ALM therapy resuscitates at hypotensive pressures by increasing CO and reducing SVR. This strategy is associated with heart and brain protection and maintained tissue O2 delivery. Translational studies are required to determine reproducibility and optimal component dosing. ALM therapy may find wide utility in prehospital and far-forward military environments.

Military MedicineVol. 189(Supplement_3)
James Cook University (AU)
Good health and well-being
Openalex Percentile: Top 16%
Trauma, Hemostasis, Coagulopathy, Resuscitation
1.69
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