Optimization of a Lethal, Combat-Relevant Model of Sterile Inflammation in Mice for Drug Candidate Screening
We optimized a TBX mouse model of SIRS/MODS for the purpose of evaluating novel therapeutic interventions to prevent trauma-related pathophysiologies in wounded Service Members. Negative effects of K/X on lethality of TBX should be further evaluated, particularly in the light of widespread use of ketamine in treatment of pain. By mimicking muscle crush, bone fracture, and necrosis, the TBX model has pleiotropic effects on physiology and immunology that make it uniquely valuable as a screening tool for the evaluation of novel therapeutics against trauma-induced SIRS/MODS.
Authors
- Rania Abu-Taleb
- Derese Getnet (ORCID: https://orcid.org/0000-0002-2619-4910)
- Alexander G. Bobrov
- Radmila Pavlović (ORCID: https://orcid.org/0000-0002-2128-4589)
- Rex Jeya Rajkumar Samdavid Thanapaul (ORCID: https://orcid.org/0000-0002-5760-9437)
- Christine Czintos
- Lacie M. Werner (ORCID: https://orcid.org/0000-0001-8751-6170)
- Kariana E Rios (ORCID: https://orcid.org/0000-0003-2500-0325)
- Yonas A. Alamneh
- Dawn Hull
- Wanwen Su
- Vlado Antonic (ORCID: https://orcid.org/0000-0003-2118-9204)
- Sun‐Joo Lee (ORCID: https://orcid.org/0000-0002-3756-7364)
- Clara Leung
Institutions
- Oak Ridge Associated Universities (US)
- National Academies of Sciences, Engineering, and Medicine (US)
- Oak Ridge Institute for Science and Education
- Walter Reed Army Institute of Research (US)
Publication Details
- Journal
- Military Medicine
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1093/milmed/usae233
- Citations
- 1
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- Combat Casualty Care Research Program