Association between thermogenic brown fat and genes under positive natural selection in circumpolar populations
Our results suggest a marginal but significant association between LEPR SNPs. However, robust supporting evidence was not established for the involvement of other loci under positive natural selection in cold adaptation through BAT thermogenesis in East Asian adults. Given the pleiotropic function of these genes, factors other than cold adaptation through BAT thermogenesis, such as diet adaptation, may contribute to positive natural selection at these loci.
Authors
- Takeshi Yoneshiro (ORCID: https://orcid.org/0000-0001-5298-5831)
- Kazuhiro Nakayama (ORCID: https://orcid.org/0000-0003-1616-6163)
- Masayuki Saito (ORCID: https://orcid.org/0000-0002-3058-3003)
- Yuka Ishida
- Mami Matsushita
Institutions
- Hokkaido University of Science (JP)
- Tohoku University (JP)
- Hokkaido University (JP)
- Tenshi College (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Journal of PHYSIOLOGICAL ANTHROPOLOGY
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1186/s40101-024-00368-1
- Citations
- 7
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Japan Society for the Promotion of Science