Genomic characterization of AML with aberrations of chromosome 7: a multinational cohort of 519 patients
This work unraveled formerly underestimated genetic lesions and provides a comprehensive overview of the spectrum of recurrent gene mutations and their clinical relevance in AML with abn(7). KMT2C mutations are among the most frequent gene mutations in this heterogeneous AML subgroup and warrant further functional investigation.
Authors
- Hsin‐An Hou (ORCID: https://orcid.org/0000-0003-2780-4845)
- Patrı́cia Silva (ORCID: https://orcid.org/0000-0002-6613-9000)
- David C. Linch (ORCID: https://orcid.org/0000-0002-9988-5528)
- Wen‐Chien Chou (ORCID: https://orcid.org/0000-0003-2967-698X)
- Jordi Esteve
- Christine Terré
- Robert Altwasser (ORCID: https://orcid.org/0009-0002-6216-6068)
- Adriane Halik (ORCID: https://orcid.org/0000-0001-7858-5326)
- Laurène Fenwarth (ORCID: https://orcid.org/0000-0003-2808-4843)
- Jan Krönke (ORCID: https://orcid.org/0000-0002-4649-0506)
- Klaus Hans Metzeler (ORCID: https://orcid.org/0000-0003-3920-7490)
- Kenichi Yoshida (ORCID: https://orcid.org/0000-0003-4612-2778)
- Marlon Tilgner (ORCID: https://orcid.org/0000-0003-3196-6214)
- Matthieu Duchmann (ORCID: https://orcid.org/0000-0002-7299-4572)
- Lars Bullinger (ORCID: https://orcid.org/0000-0002-5890-5510)
- Anna Dolnik (ORCID: https://orcid.org/0000-0003-4166-2900)
- Robert K. Hills (ORCID: https://orcid.org/0000-0003-0166-0062)
- Bob Löwenberg (ORCID: https://orcid.org/0000-0001-8982-5217)
- Frédérik Damm (ORCID: https://orcid.org/0000-0001-5553-1173)
- Loïc Vasseur (ORCID: https://orcid.org/0000-0001-9065-0477)
- Friederike Christen (ORCID: https://orcid.org/0000-0001-8868-2533)
- Michael Heuser (ORCID: https://orcid.org/0000-0001-5318-9044)
- Konstanze Döhner (ORCID: https://orcid.org/0000-0002-2261-9862)
- Rosemary E. Gale (ORCID: https://orcid.org/0000-0002-0103-1787)
- Martin Szyska
- Natàlia Estrada (ORCID: https://orcid.org/0000-0001-8193-4857)
- Olga Blau (ORCID: https://orcid.org/0000-0002-4304-5079)
- Peter J.M. Valk (ORCID: https://orcid.org/0000-0002-8857-9461)
- Marta Pratcorona (ORCID: https://orcid.org/0000-0001-6375-596X)
- Hartmut Döhner (ORCID: https://orcid.org/0000-0003-2116-5536)
- Nikolaus Jahn (ORCID: https://orcid.org/0009-0001-0741-1166)
- K Kopp
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Université de Lille (FR)
- Hospital de Sant Pau (ES)
- Erasmus MC (NL)
- Medizinische Hochschule Hannover (DE)
- Humboldt-Universität zu Berlin (DE)
- University of Oxford (GB)
- London Cancer (GB)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut pour la Recherche sur le Cancer de Lille (FR)
- Hospital Clínic de Barcelona (ES)
- German Marine Research Consortium (DE)
- University Hospital Leipzig (DE)
- National Taiwan University Hospital (TW)
- Hôpital Saint-Louis (FR)
- Erasmus MC Cancer Institute (NL)
- University Hospital Ulm (DE)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Institut de Recerca Sant Pau (ES)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- University College London (GB)
- Martin Luther University Halle-Wittenberg (DE)
- Universitat de Barcelona (ES)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Journal of Hematology & Oncology
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1186/s13045-024-01590-1
- Citations
- 18
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 8.18
Funders
- National Cancer Research Institute
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Charité – Universitätsmedizin Berlin
- José Carreras Leukämie-Stiftung
- Deutsche Krebshilfe
- Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung
- Deutschen Konsortium für Translationale Krebsforschung
- Berlin Institute of Health