Immune checkpoint gene signature assesses immune infiltration profiles in bladder cancer and identifies KRT23 as an immunotherapeutic target
This study systematically and comprehensively analyzed the expression profile of immune checkpoint genes, and established the ICG signature to investigate the differences in ICGs expression and tumor immune microenvironment, which will help risk stratification and accelerate precision medicine. Finally, we identified KRT23 as the most critical model gene, and highlighted KRT23 as a potential target to enhance immunotherapy against BLCA.
Authors
- Dongshan Chen (ORCID: https://orcid.org/0000-0003-3479-3144)
- Haoyuan Cao (ORCID: https://orcid.org/0000-0001-7083-6717)
- Zengchi Han (ORCID: https://orcid.org/0009-0004-1544-5229)
- Xiang Zheng (ORCID: https://orcid.org/0000-0003-2442-9816)
- Wei Wang (ORCID: https://orcid.org/0000-0003-2642-3338)
- Haojun Wang (ORCID: https://orcid.org/0009-0003-1126-3228)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Capital Medical University (CN)
- Jining Traditional Chinese Medicine Hospital (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- Qilu Hospital of Shandong University (CN)
- Beijing Chaoyang Emergency Medical Center (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-08-19
- DOI
- https://doi.org/10.1186/s12885-024-12790-w
- Citations
- 1
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.57